Early detection of Congestive Heart
Failure using Smartphones
Problem
Heart Failure a major cause of fatality
3.top cause of fatality
Top reason for hospitalization
Costly and time consuming tests
ca. 445.000 hospitalizations recorded in 2015
ca. 50.000 cases/year
Costs: 3,2 Billion € at an estimated 2,7 Mio cases
Idea
Hospitalizations could be avoided
Need amulatory care and monitoring
Top reason for hospitalization
Costly and time consuming tests
● > 1 Mio hospitalizations every year
● Average annual number of emergency calls per doctor : 48 (courtesy BARMER GEK 2009)
Researchers have long considered CHF to be an ambulatory care sensitive condition (ACSC).
Hospitalizations of patients with ACSCs could often be avoided if these patients received
timely and appropriate medical care in outpatient settings
● Costs: 30.7 Billion $ to the nation at an estimated 5.7 Mio cases
● In the developed western countries it takes up about 1-2% of the Health Care budget
Market size
CHF Patient
readmissions
1 in 4 rehospitalized for
heart failure within 30 days
Average hospitalization
€1.5k
Average cost of
hospitalization per day
€15 B
Addressable market
600k
Heart attack survivors
alone in US
1 of 4 patients develop
CHF within 4 years of first
attack
€1.5k
Average cost of
hospitalization per day
€900 M
Addressable market
Heart attack
survivors
Solution
A personal Database
Uniform and repeatable Tests via Smartphone
With the help of a Smartphone the patient could record the health of his heart .
The recorded data is continuously uploaded to the server, and an AI analysis is
instantly delivering the result to the user.
This enables Zenor-App to alert the patients of an approaching Heart Failure.
Technology
Proven principles
Clinical trials from John Hopkins Institute USA
1. Test February 2013 with 14 Subjects: 78% Sensitive , 100% Specific
Source: Link
2. Test April 2016 mit 81 Personen: 70% Sensitive , 86% Specific
Source: Link1, link2
A NONINVASIVE HAND-HELD DEVICE IDENTIFIES ELEVATED LEFT VENTRICULAR FILLING PRESSURE
USING FINGER PHOTOPLETHYSMOGRAPHY DURING THE VALSALVA MANEUVER
Technologie
Accuracy of Diagnosis
Accuracy
False�
Alarm
Detection
ECG
30%
80%
Stress�
Test
28%
67%
Dynamic
Auscultation
9%
70%
Zencorlabs
9%
70%
Blood
Test
26%
90%
Echo
Cardiography
6%
80%
Left�heart/Pulmonary�
catheterization
4%
96%
Product
Zencorlabs Version
Quick check at Doctor’s office
Potential
Prevention and Control
Heart Failure
follow up
Autonomic nervous
system test
SVT treatment
Atrial Fibrillation
test
Hypertension
control
Revenue Model
Revenue
Market Customer Test Context Billing methods
B2C Primary care Non invasive LVEDP
test
Early Heart Failure
detection
CPT 93799
B2C Ambulance SVT treatment Revert Valsalva
Maneuver
Emergency inventory
(Australia)
B2C Primary care CARTs - Cardiac
Autonomic Reflex
HRV, E/I Ratio, Valsalva
Ratio, 30:15 test
CPT 95921
CPT 95943
B2B Pharma Non-Clinical
Cardiovascular
Safety Testing
Cardiac safety tests for
Antidepressant agents
Entry Fee +
Subscription
B2C Home
monitoring
Daily Zencoreye
monitoring + LVEDP
Follow up after Acute
Myocardial Infarction
Over The Counter
(patient is paying)
Company Placement Sensing
technology
BP
technology
Valsalva
Maneuver
Price
fingertip PPG continuous no 20K $
fingertip PPG+ECG continuous yes 15K $
arm sonar continuous no 400 $
wrist PPG+ECG spot no 300 $
fingertip piezo+ECG spot no 400 $
fingertip PPG spot yes 250 $
fingertip mobile camera spot no 300 $
fingertip mobile camera relative
continuous
yes 30 $
Competitive analysis
Quick comparison
Current Status
Prototype II: Clinical study
Current: Prototype 2
· Technology exists
· The devices are in production
· Next step: Clinical trial
Prototype 1
· Technical validation
FAQ
Costumer info
Can Valsalva Manoeuvre cause irreversible damage
Can Valsalva Manoeuvre cause fainting?
What does ZencorEye stand for?
How often am I allowed to test myself?
In case the Valsalva Manoeuvre (VM) is performed according to Zencorlabs
guidelines it can't cause irreversible damage.
There has been registered cases of elderly people fainting while performing a
bowel movement in the Lavatory. Zecorlabs is employing the Controlled VM
where constant and measured effort is applied. There are noknown fainting
cases due to CVM.
ZencorEye is a graphic reflection of the clinicalparameter of Left Ventricular
End Diastolic Pressure (LVEDP) that is used to diagnose Heart Failure by
clinicians.
CVM is not recommended to perform more than three times in a row.
Otherwise the maneuver can cause a headache. A pause of at least one hour
is recommended between each three attempts.
FAQ
Costumer info
Is it possible to perform the inhaling maneuver as well?
What if I don't see the expected ZencorEye shape given a PASS result?
How reliable is Zencorlabs test for early Heart Failure detection?
Can I use The Whistle to stop a SVT attack?
Definitely, the respective maneuver is called Müller and it is used for several
purposes in medicine.
In this case we encourage you to reach out to our clinical assistance on
info@zencorlabs.com.
Zencorlabs clinical study results are not published yet but according to
contemporary studies based on the CVM 84% of the measurement will fall in
the 4 mmHg error from the Swan Ganz catheter state of the art LVEDP
measurement.
VM is often used to stop SVT attacks. According clinical research standard
VM archives to stop 17% of the SVT attacks while a Modified VM stopes
43%.
FAQ
Costumer info
Can I adjust my Heart Failure meds to my ZencorEye reading?
Can The Whistle be used to test children?
My ZencorEye is shrinking but I feel well, what shall I do?
How often Zencorlabs test is recommended?
It is not recommended unless done under Zencorlabsapproved cardiologist
surveillance.
Definitely, if the child is able to perform the CVM properly.
In this case we encourage you to reach out to our clinical assistance on
info@zencorlabs.com.
The recommended testing frequency is two times per week right after waking
up.
Pulmonary hypertension patients are recommended to avoid performing the
CVM due to cardiovascular danger.
What group of patients should avoid Zencorlabs test?